Cryosurgery of Hepatic Malignancy-Is Cryosurgery Appropriate Treatment for hepatic malignancies?
간암 냉동수술의 초기 경험-간암에 냉동수술이 유용하게 적응될 수 있는가?
간암 냉동수술의 초기 경험-간암에 냉동수술이 유용하게 적응될 수 있는가?
Dong Hoon Shin, M.D.
신동훈
Department of Surgery, Kosin University College of Medicine. Chang Kee Ryo Memorial Liver Institute.
고신의대 외과학 교실, 장기려 기념 간 연구소.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract- Purpose: Hepatic resection has proven to be an effective treatment for primary and secondarymalignant hepatic tumors, but the majority of patients cannot be treated with resection.Candidates for cryosurgery are patients who are considered unresectable, but who have noevidence of disease outside the liver. The purpose of cryosurgery is to destroy all present tumors(including a margin of healthy tissue) by freezing them. The purpose of this study was toevaluate clinical outcomes after cryosurgery for hepatic malignancies.Methods: Freezing is performed using high pressure argon or liquid nitrogen and utilizing theJoule-Thomson effect. Two freeze-thaw cycles performed at each location have been previouslydocumented to increase tissue destruction. Mechanisms of freezing-induced cellular destructioninclude intracellular and extracellular ice crystal formation, cell membrane damage, cellulardehydration, ischemic damage from thrombosed vessels, and apoptosis. Cryosurgery isperformed through open placement of cryoprobes in the tumor, using laparoscopic andpercutaneous approaches. The cryosurgery procedure is usually monitored withultrasonography, computed tomography, and magnetic resonance imaging.Results: Hepatic cryosurgery was performed in 6 patients (follow-up period more than 1 year) atour hospital. We noted no local tumor recurrence, and we achieved effective treatment ofhepatic malignancies.Conclusion: Hepatic cryosurgery is increasingly recognized as a safe and effective treatmentmodality for nonresectable patients, or as a modality to be used in conjunction with liverresection.
- Keywords : Hepatic malignancy, Cryosurgery
- November 2024, 28 (4)
Full Text(PDF) Free- Social Network Service
-
- Services
- Cited By Articles
-
CrossRef (0)
