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The Analysis of the Cholesterol Contents of Intrahepatic Duct Stones in the West Gyeongnam Region
서부 경남지방에서 간내결석의 콜레스테롤 성분 분석
Korean Journal of HBP Surgery 2007 Dec;11(4):22-7
Published online December 30, 2007
Copyright © 2007 Korean Journal of Hepato-Biliary-Pancreatic Sursery.

Jeong-In Park, M.D., Ji-Ho Park, M.D., Young-Tae Ju, M.D., Chi- Young Jeong, M.D., Eun-Jung Jung, M.D., Young-Joon Lee, M.D., Sang-Kyung Choi, M.D., Woo-Song Ha, M.D., Soon-Tae Park, M.D., Tae-Hyo Kim1, M.D., Ok-Jae Lee1, M.D., Soon-Chan Hong*, Ph.D.
박정인, 박지호, 주영태, 정치영, 정은정, 이영준, 최상경, 하우송, 박순태, 김태효1, 이옥재1, 홍순찬

Department of Surgery, Internal Medicine1, Gyeongsang National University College of Medicine, Jinju, Korea
경상대학교 의과대학 외과학교실, 내과학교실1
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Purpose: Hepatolithiasis is a recurrent disease and common in Far East Asia. In Korea, almostall intrahepatic duct (IHD) stones were pigment stones 30~40 years ago. The nationwidecooperative study showed a higher cholesterol content of IHD stones compared to the previousdata. Some reports have shown a close relationship between urbanization and the cholesterolcontent of stones. The purpose of this study was to evaluate the cholesterol content of IHDstones in the West Gyeongnam region and evaluate the associated clinical and demographicvariables.Methods: The IHD stones were removed surgically from twenty patients who hadhepatolithiasis between July 2005 and April 2007. The stones were grouped by their grossfindings. The cholesterol contents were measured quantitatively by infrared spectrophotometryand compared with the clinical variables.Results: Among twenty patients, 19 had pigment stones and only one had gross evidence of acholesterol stone. The cholesterol content of the stones were 30%~50% in 13 patients, 50~70%in 6 patients and over 70% in one patient. In urban patients, the cholesterol contents of the IHDstones were higher (567.029 mg/g) than in rural patients (421.822 mg/g)(p<0.05). All stones inrural patients were pigment stones; the stones of urban patients consisted of 5 pigment, 6 mixedand 1 cholesterol stone (p<0.05).Conclusion: The mean cholesterol content of the IHD stones was 508.946 mg/g; the content ofthe stone was significantly related to the residence of the patients. These results suggest that thecholesterol content of IHD stones are likely to increase in West Gyeongnam as urbanizationincreases.
Keywords : Intrahepatic duct stone, cholesterol, infrared spectrophotometry

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