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Significance of Bioelectrical Impedance during Ischemia-Reperfusion Injury in the Rabbit''s Liver
간의 허혈 재관류 손상 측정 도구로서의 Bioelectrical Impedance의 의의
Korean Journal of HBP Surgery 2006 Mar;10(1):29-33
Published online March 30, 2006
Copyright © 2006 Korean Journal of Hepato-Biliary-Pancreatic Sursery.

Yong Seok Cho1, M.D., Sung Su Yun1,2, M.D., Hyun Jin Shin2, Ph.D., Hyun Soo Ahn2, Ph.D. Dong Shik Lee1,M.D., Hong Jin Kim1, M.D.
조용석1, 윤성수1,2, 신현진2, 안현수2,이동식1, 김홍진1

1 Department of Surgery and 2 Research Institute of Biomedical Engineering, Yeungnam University College of Medicine, Daegu, Korea
1영남대학교 의과대학 외과학교실, 2영남대학교 의료공학연구소
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Purpose: During liver resection and transplantation, liver is damaged by ischemia-reperfusion injury. Until now, there is no approvedmethod to measure or predict the extent of liver injury during theoperation. This is the preliminary study to make the real timemonitoring system by quantification of bioelectrical impedance andischemia-reperfusion injury in liver.Methods: Male Newzealand white rabbits(body weight 3.5-4.0 kg)were used. We observed changes of bioelectrical impedance duringischemia and reperfusion injury according to frequency(120 Hz-100KHz). Bioelectrical impedance of liver tissue were measured every 5minutes interval with two mono-polar needle coated with platinumusing LCR meter (GS-4311B, ANDO, Japan). Cell viability wasassessed by metabolic capacity of fatty acid (palmitic acid metabolicrate) and histologic examination (H&E stain) at every 30 minutesinterval during 120 minutes ischemia.Results: Liver bioelectrical impedance was changedsignificantly(p<0.05) during ischemia in lower frequency compared tothose of higher frequency. Bioelectrical impedance(120 Hz)increased during ischemia and returned to base line level afterreperfusion. The level of bioelectrical impedance(120 Hz) increasedgradually after ischemia for 1 hour. After 1 hour, the level ofbioelectrical impedance had tendency to maintain plateau. Palmiticacid oxidation rate were not changed significantly during 120 minutesischemia and there were no significant difference in histologicexamination.Conclusion: We found the possible role of bioelectrical impedance tomeasure and predict the extent of ischemia-reperfusion injury.
Keywords : Liver, Ischemia, Reperfusion, Bioelectrical Impedance

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