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Effect of early oral nutrition supplement using Encover in patients undergoing hepato-biliary-pancreatic surgery
Ann Hepatobiliary Pancreat Surg
Published online March 11, 2022;
Copyright © 2022 The Korean Association of Hepato-Biliary-Pancreatic Surgery.

Byeong Jun Lee, Joon Seong Park, Hyung Sun Kim, Dong Sup Yoon, Jin Hong Lim

Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
Correspondence to: Jin Hong Lim
Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, 20 Eonju-ro 63-gil, Gangnam-gu, Seoul 06229, Korea
Tel: +82-2-2019-3370, Fax: +82-2-3462-5994, E-mail:
Received October 28, 2021; Revised November 15, 2021; Accepted November 17, 2021.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Backgrounds/Aims: Early recovery after surgery has become a popular trend. The aim of this study was to evaluate effect of nutritional intervention using Encover, an oral nutritional supplement, in patients undergoing hepato-biliary-pancreatic surgery.
Methods: This single center, prospective case-control study was conducted in Gangnam Severance Hospital from September 2018 to April 2019. Through randomization, patients were divided into an experimental group (30 patients) and a control group (30 patients). At postoperative seven days, the experimental group was instructed to take two packs of Encover (JW Pharmaceutical, Seoul, Korea) daily for seven days. Body cell mass index was measured at seven days after surgery and 14 days after discharge and Patient-Generated Subjective Global Assessment (PG-SGA) was performed at 14 days after discharge.
Results: Body cell mass index during outpatient follow-up was significantly decreased compared to that at discharge in both groups. However, the amount of body cell mass index showed no significant difference between postoperative seven days and outpatient follow- up in either group. During outpatient follow-up, the experimental group had a higher mean value of PG-SGA score than the control group (11.32 ± 3.46 vs. 9.48 ± 3.97; p = 0.037).
Conclusions: Short-term Encover doses after surgery may not produce significant results in weight gain or other body cell mass index. Encover did not significantly affect other dietary conditions based on PG-SGA.
Keywords : Nutritional support; Supplementary feeding; Diertary supplements; Enhanced recovery after surgery; Enteral nutrition


May 2022, 26 (2)
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