Demographic and clinicopathological characteristics of the patients with pT2–4 stages (n = 272)
| FB-GBC (n = 199) |
NC-GBC (n = 73) |
||
|---|---|---|---|
| Age (yr) | 69.1 ± 10.2 | 69.8 ± 8.9 | 0.621 |
| Female sex | 103 (51.8) | 42 (57.5) | 0.398 |
| BMI | 23.9 ± 3.9 | 23.9 ± 3.7 | 0.923 |
| ASA class < 3 |
146 (84.9) | 63 (88.7) | 0.419 |
| ECOG status < 2 |
145 (90.6) | 62 (91.2) | 0.887 |
| Acute cholecystitis | 49 (24.6) | 19 (26.0) | 0.909 |
| PTGBD insertion | 18 (9.0) | 8 (11.0) | 0.650 |
| Symptomatic GBC |
113 (73.9) | 56 (86.2) | 0.047 |
| CA 19-9 ≥ 37.0 (U/mL) |
29 (17.5) | 27 (45.0) | < 0.001 |
| Laparoscopic approach | 132 (66.3) | 33 (45.2) | 0.002 |
| 2nd look operation | 47 (23.6) | 18 (24.7) | 0.887 |
| Bile duct resection | 21 (10.6) | 27 (37.0) | < 0.001 |
| Surgical extent | 0.003 | ||
| SC only | 49 (24.6) | 12 (16.4) | |
| SC + LND | 22 (11.1) | 10 (13.7) | |
| Wedge resection | 93 (46.7) | 27 (37.0) | |
| S4b + 5 segmentectomy | 34 (17.1) | 15 (20.5) | |
| Major liver resection |
1 (0.5) | 9 (12.3) | |
| ICPN |
7 (5.5) | 1 (1.6) | 0.222 |
| Tumor size (mm) | 32.9 ± 19.1 | 36.7 ± 26.1 | 0.319 |
| Histologic grade, WHO |
< 0.001 | ||
| G1 | 52 (26.9) | 5 (7.2) | |
| G2 | 114 (59.1) | 42 (60.9) | |
| G3 | 25 (13.0) | 20 (29.0) | |
| G4 | 2 (1.0) | 2 (2.9) | |
| pT-stage | 0.002 | ||
| T2 | 163 (81.9) | 48 (65.8) | |
| T3 | 34 (17.1) | 22 (30.1) | |
| T4 | 2 (1.0) | 3 (4.1) | |
| pN-stage | 0.015 | ||
| Nx or N0 | 150 (75.4) | 44 (60.3) | |
| N1–2 | 49 (24.6) | 29 (39.7) | |
| R0 resection | 183 (92.4) |
51 (69.9) | < 0.001 |
| Lymphovascular invasion |
72 (36.9) | 35 (59.3) | 0.040 |
| Perineural invasion |
47 (24.7) | 34 (48.6) | < 0.001 |
| Adjuvant treatment | 68 (34.2) | 39 (53.4) | 0.005 |
| Recurrence |
63 (33.7) | 45 (63.4) | < 0.001 |
Values are presented as mean ± standard deviation or number (%).
FB-GBC, gallbladder cancer in the fundus/body; NC-GBC, gallbladder cancer in the neck/cystic duct; BMI, body mass index; ASA, American Society of Anesthesiologists; ECOG, Eastern Cooperative Oncology Group; PTGBD, percutaneous transhepatic gallbladder drainage; SC, simple cholecystectomy; LND, lymph node dissection; ICPN, intracholecystic papillary neoplasm; WHO, World Health Organization.
a)The total sample size may not equate to the breakdown because of missing data.
b)Major liver resection is defined as liver resection ≥ 3 hepatic segments.