Demographic and clinicopathological characteristics of all the patients (n = 372)
| FB-GBC (n = 282) |
NC-GBC (n = 90) |
||
|---|---|---|---|
| Age (yr) | 68.0 ± 11.3 | 68.8 ± 9.7 | 0.477 |
| Female sex | 138 (48.9) | 53 (57.8) | 0.144 |
| BMI | 24.1 ± 3.5 | 23.9 ± 3.6 | 0.713 |
| ASA class < 3 |
211 (85.8) | 77 (89.5) | 0.376 |
| ECOG status < 2 |
199 (87.7) | 76 (91.6) | 0.337 |
| Acute cholecystitis | 65 (23.0) | 26 (28.6) | 0.279 |
| PTGBD insertion | 24 (8.5) | 11 (12.1) | 0.304 |
| Symptomatic GBC |
160 (76.9) | 67 (84.8) | 0.142 |
| CA 19-9 ≥ 37.0 (U/mL) |
34 (14.6) | 30 (39.0) | < 0.001 |
| Laparoscopic approach | 200 (70.9) | 45 (50.0) | 0.013 |
| 2nd look operation | 54 (19.1) | 19 (21.1) | 0.707 |
| Bile duct resection | 26 (9.2) | 29 (32.2) | < 0.001 |
| Surgical extent | 0.002 | ||
| SC only | 96 (34.0) | 22 (24.4) | |
| SC + LND | 37 (13.1) | 13 (14.4) | |
| Wedge resection | 107 (37.9) | 29 (32.2) | |
| S4b + 5 segmentectomy | 38 (13.5) | 17 (18.9) | |
| Major liver resection |
4 (1.4) | 9 (10.0) | |
| ICPN |
16 (8.7) | 1 (1.3) | < 0.001 |
| Tumor size (mm) | 28.6 ± 17.7 | 35.0 ± 25.1 | 0.034 |
| Histologic grade, WHO |
< 0.001 | ||
| G1 | 101 (37.5) | 13 (15.5) | |
| G2 | 137 (50.9) | 49 (58.3) | |
| G3 | 30 (11.2) | 21 (25.0) | |
| G4 | 2 (0.7) | 2 (2.4) | |
| pT-stage | 0.001 | ||
| T1 | 82 (29.2) |
17 (18.9) | |
| T2 | 163 (58.0) |
48 (53.3) | |
| T3 | 34 (12.1) |
22 (24.4) | |
| T4 | 2 (0.7) |
3 (3.3) | |
| pN-stage | 0.004 | ||
| Nx or N0 | 231 (81.9) | 61 (67.8) | |
| N1–2 | 51 (18.1) | 29 (32.2) | |
| R0 resection | 265 (94.3) |
68 (75.6) | < 0.001 |
| Lymphovascular invasion |
79 (28.4) | 37 (42.0) | 0.029 |
| Perineural invasion |
48 (18.0) | 34 (39.1) | < 0.001 |
| Adjuvant treatment | 76 (27.0) | 40 (44.4) | 0.002 |
| Recurrence |
70 (25.9) | 49 (55.7) | < 0.001 |
Values are presented as mean ± standard deviation or number (%).
FB-GBC, gallbladder cancer in the fundus/body; NC-GBC, gallbladder cancer in the neck/cystic duct; BMI, body mass index; ASA, American Society of Anesthesiologists; ECOG, Eastern Cooperative Oncology Group; PTGBD, percutaneous transhepatic gallbladder drainage; SC, simple cholecystectomy; LND, lymph node dissection; ICPN, intracholecystic papillary neoplasm; WHO, World Health Organization.
a)The total sample size may not equate to the breakdown because of missing data.
b)Major liver resection is defined as liver resection ≥ 3 hepatic segments.