Multivariable analysis of prognostic factors using stepwise backward selection in the training cohort
| HR (95% CI) | SE | z | Coefficient | ||
|---|---|---|---|---|---|
| HBs-Ag positive | 0.57 (0.35–0.93) | 0.247 | –2.265 | 0.02 | –0.560 |
| HCV-Ab positive | 0.69 (0.49–0.96) | 0.170 | –2.223 | 0.03 | –0.378 |
| Albumin | 0.41 (0.30–0.57) | 0.164 | –5.389 | < 0.001 | –0.882 |
| AST | 1.01 (1.00–1.01) | 0.002 | 3.274 | 0.001 | 0.006 |
| Prothrombin activity | 0.99 (0.98–1.00) | 0.006 | –1.616 | 0.11 | –0.009 |
| AFP ≥ 20 (ng/mL) | 1.41 (1.05–1.87) | 0.147 | 2.322 | 0.02 | 0.341 |
| Beyond up-to-seven criterion | 1.60 (1.17–2.19) | 0.159 | 2.961 | 0.003 | 0.472 |
| ASAL score parameters | |||||
| Albumin | 0.35 (0.27–0.47) | 0.142 | –7.358 | < 0.001 | –1.043 |
| AST | 1.01 (1.00–1.01) | 0.002 | 3.334 | < 0.001 | 0.005 |
The sixteen parameters tested were as follows: age, sex, hepatitis B virus antigen S (HBs-Ag), anti-hepatitis C virus antibody (HCV-Ab), total bilirubin, albumin, aspartate aminotransferase (AST), alanine aminotransferase, platelet counts, prothrombin activities, indocyanine green retention rates at 15 minutes, alpha-fetoprotein (AFP) ≥ 20 ng/mL, des-γ-carboxy prothrombin ≥ 40 mAu/mL, Milan and up-to-seven criteria, and era of hepatectomy (2004–2009, 2010–2016, or 2017–2023).
HR, hazard ratio; CI, confidence interval; SE, standard error; ASAL, aspartate aminotransferase-albumin.