Annals of Hepato-Biliary-Pancreatic Surgery

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Table. 3.

Table. 3.

Relationship between PNI and clinico-pathological parameters

Variable Albumin Prealbumin TC LN% LNC PNI PNI < 40/≥ 40a)
Age –0.243** –0.218* –0.106 –0.013 –0.152* –0.249** 68.5 ± 9.1/
Sex 63.9 ±10.9**
Male (n = 127) 4.0 ± 0.4 22.9 ± 5.6 179 ± 39 29 ± 10 1569 ± 566 40.0 ± 5.5 57/70 (56)
Female (n = 55) 3.8 ± 0.4* 20.0 ± 7.3 199 ± 63** 31 ± 11 1578 ± 668 38.9 ± 4.1 34/21 (48)
Disease
HCC (n = 90) 3.9 ± 0.4 19.8 ± 5.7 165 ± 31 31 ± 10 1645 ± 654 39.6 ± 6.0 47/43
ICC (n = 12) 3.8 ± 0.4 23.9 ± 5.2 177 ± 34 29 ± 10 1532 ± 510 38.6 ± 3.5 8/4
Liver metastasis (n = 46) 3.9 ± 0.4 23.5 ± 5.4 199 ± 64 27 ± 9 1554 ± 494 39.8 ± 4.5 20/26
ECC (n = 12) 3.7 ± 0.4 17.2 ± 5.3 197 ± 94 25 ± 13 1298 ± 680 38.2 ± 4.0 8/4
GBC (n = 16) 4.0 ± 0.4 25.8 ± 8.0 187 ± 26 28 ± 10 1382 ± 384 40.4 ± 3.5 7/9
Other (n = 6) 4.0 ± 0.4 22.8 ± 10.5 186 ± 31 29 ± 10 1664 ± 774 41.5 ± 4.9 1/5
Liver functional parameter -
ICGR15 –0.296** –0.335** –0.203** 0.181* –0.078 –0.339**
LHL15 0.184** 0.204* –0.226** –0.225** –0.020 0.197**
Prothrombin activity (%) 0.133 0.213* 0.305** –0.009 0.068 0.159*
Total bilirubin (mg/dL) 0.090 0.090 0.037 0.043 –0.100 0.093
Hyaluronic acid (ng/mL) –0.340** 0.212* –0.088 0.086 –0.080 –0.399**
Surgical record
Extent of hepatectomy
Major (n = 31) 3.7 ± 0.4 18.9 ± 6.7 188 ± 74 26 ± 11 1429 ± 562 38.0 ± 4.0 30/12
Minor (n = 143) 4.0 ± 0.4 22.6 ± 6.2 176 ± 38 31 ± 9 1620 ± 607 40.2 ± 5.4 58/78
Transection time 0.085 –0.162 0.010 0.021 0.027 0.092 -
Operation time (min) –0.139 –0.171 0.159 –0.204 –0.085 –0.057 -
Blood loss (mL) –0.122 –0.080 0.026 –0.120 –0.172* –0.097 -
Transfusion –0.091 –0.068 0.024 –0.127 –0.170* –0.085 -
No 3.9 ± 0.4 22.3 ± 6.3 177 ± 43 31 ± 10 1644 ± 604 40.2 ± 4.0
Yes (n = 37) 3.8 ± 0.5* 19.7 ± 6.5 189 ± 68 26 ± 10* 1329 ± 540** 37.6 ± 7.9
Postoperative functionb) -
Total bilirubin –0.055 –0.003 –0.063 0.083 –0.028 –0.026
Alanine aminotransferase 0.013 0.043 0.077 –0.125 0.041 0.032
Prothrombin activity 0.133 0.277** 0.178* –0.024 –0.015 –0.014
Platelet 0.056 0.119 0.087 –0.130 –0.069 0.057
C-reactive protein 0.020 –0.007 0.083 –0.061 0.090 0.032
Postoperative coarse
Total complication
No 4.0 ± 0.4 22.9 ± 6.3 177 ± 40 31 ± 9 1,612 ± 545 40.1 ± 5.4 59/72 (55)
Yes (n = 45) 3.8 ± 0.4** 19.1 ± 6.2** 187 ± 68 28 ± 12 1,480 ± 740 38.5 ± 4.2* 28/17 (38)
HT-related complication
No 4.0 ± 0.4 22.7 ± 6.3 177 ± 39 30 ± 10 1,597 ± 606 40.1 ± 5.3 66/82 (75)
Yes (n = 28) 3.7 ± 0.4** 17.4 ± 4.8** 189 ± 84 27 ± 10 1,482 ± 581 37.7 ± 4.0** 21/7 (46)**
Liver failure
No 3.9 ± 0.4 21.9 ± 6.4 180 ± 49 30 ± 10 1,590 ± 600 39.4 ± 5.3 84/88
Yes (n = 4) 3.7 ± 0.3 18.5 ± 6.8 148 ± 37 24 ± 6 1,063 ± 490 38.9 ± 6.0 3/1
Intra-abdominal infection
No 3.9 ± 0.4 22.0 ± 6.5 178 ± 46 30 ± 10 1,589 ± 596 39.8 ± 5.2 79/84
Yes (n = 13) 3.8 ± 0.4 19.4±5.5 197 ± 75 30 ± 12 1,452 ± 686 38.7 ± 4.3 8/5
Ascites
No 3.9 ± 0.4 21.8 ± 6.6 180 ± 50 30 ± 10 1,567 ± 606 39.7 ± 5.2 78/85
Yes (n = 13) 3.8 ± 0.4 20.8 ± 1.4 164 ± 33 29 ± 13 1,718 ± 548 38.9 ± 3.8 9/4
Bile leak
No 3.9 ± 0.4 22.4 ± 6.2 175 ± 39 30 ± 10 1,598 ± 597 39.9 ± 5.2 76/84
Yes (n = 16) 3.6 ± 0.5* 16.7 ± 6.0* 215 ± 99 24 ± 11 1,386 ± 636 37.5 ± 4.4* 11/5
Hospital stay (day) –0.194* –0.267** –0.098 –0.131 –0.123 –0.155*

Values are presented as the mean ± standard deviation. Correlation was indicated as r by Pearson co-efficiency test. Categorical data were examined by chi-squared test. Major hepatectomy included hemihepatectomy or more extended hepatectomy, minor included others.

PNI, Onodera et al. [4]’s Prognostic Nutritional Index; TC, total cholesterol; LN%, lymphocyte rate; LNC, lymphocyte counts; HCC, hepatocellular carcinoma; ICC, intrahepatic cholangiocarcinoma; ECC, extrahepatic cholangiocarcinoma; GBC, gall bladder carcinoma; ICGR15, indocyanine green retention rate at 15 minutes; LHL15, liver uptake ratio of 99m-technetium galactosyl serum albumin scintigraphy between 3 and 15 minutes; HT, hepatectomy; -, not available.

Statistically significant (*p < 0.05, **p < 0.01).

a)Parenthesis showed the prevalence of PNI over 40. b)Maximum or minimum value within 7 days after hepatectomy.

Ann Hepatobiliary Pancreat Surg 2021;25:477-84 https://doi.org/10.14701/ahbps.2021.25.4.477
© 2021 Ann Hepatobiliary Pancreat Surg