Copyright © 2013 The Annals of Hepato-Biliary-Pancreatic Surgery. / Powered by INFOrang.co, Ltd
Relationship between PNI and clinico-pathological parameters
| Variable | Albumin | Prealbumin | TC | LN% | LNC | PNI | PNI < 40/≥ 40 |
|---|---|---|---|---|---|---|---|
| Age | –0.243 |
–0.218 |
–0.106 | –0.013 | –0.152 |
–0.249 |
68.5 ± 9.1/ |
| Sex | 63.9 ±10.9 |
||||||
| Male (n = 127) | 4.0 ± 0.4 | 22.9 ± 5.6 | 179 ± 39 | 29 ± 10 | 1569 ± 566 | 40.0 ± 5.5 | 57/70 (56) |
| Female (n = 55) | 3.8 ± 0.4 |
20.0 ± 7.3 | 199 ± 63 |
31 ± 11 | 1578 ± 668 | 38.9 ± 4.1 | 34/21 (48) |
| Disease | |||||||
| HCC (n = 90) | 3.9 ± 0.4 | 19.8 ± 5.7 | 165 ± 31 | 31 ± 10 | 1645 ± 654 | 39.6 ± 6.0 | 47/43 |
| ICC (n = 12) | 3.8 ± 0.4 | 23.9 ± 5.2 | 177 ± 34 | 29 ± 10 | 1532 ± 510 | 38.6 ± 3.5 | 8/4 |
| Liver metastasis (n = 46) | 3.9 ± 0.4 | 23.5 ± 5.4 | 199 ± 64 | 27 ± 9 | 1554 ± 494 | 39.8 ± 4.5 | 20/26 |
| ECC (n = 12) | 3.7 ± 0.4 | 17.2 ± 5.3 | 197 ± 94 | 25 ± 13 | 1298 ± 680 | 38.2 ± 4.0 | 8/4 |
| GBC (n = 16) | 4.0 ± 0.4 | 25.8 ± 8.0 | 187 ± 26 | 28 ± 10 | 1382 ± 384 | 40.4 ± 3.5 | 7/9 |
| Other (n = 6) | 4.0 ± 0.4 | 22.8 ± 10.5 | 186 ± 31 | 29 ± 10 | 1664 ± 774 | 41.5 ± 4.9 | 1/5 |
| Liver functional parameter | - | ||||||
| ICGR15 | –0.296 |
–0.335 |
–0.203 |
0.181 |
–0.078 | –0.339 |
|
| LHL15 | 0.184 |
0.204 |
–0.226 |
–0.225 |
–0.020 | 0.197 |
|
| Prothrombin activity (%) | 0.133 | 0.213 |
0.305 |
–0.009 | 0.068 | 0.159 |
|
| Total bilirubin (mg/dL) | 0.090 | 0.090 | 0.037 | 0.043 | –0.100 | 0.093 | |
| Hyaluronic acid (ng/mL) | –0.340 |
0.212 |
–0.088 | 0.086 | –0.080 | –0.399 |
|
| Surgical record | |||||||
| Extent of hepatectomy | |||||||
| Major (n = 31) | 3.7 ± 0.4 | 18.9 ± 6.7 | 188 ± 74 | 26 ± 11 | 1429 ± 562 | 38.0 ± 4.0 | 30/12 |
| Minor (n = 143) | 4.0 ± 0.4 | 22.6 ± 6.2 | 176 ± 38 | 31 ± 9 | 1620 ± 607 | 40.2 ± 5.4 | 58/78 |
| Transection time | 0.085 | –0.162 | 0.010 | 0.021 | 0.027 | 0.092 | - |
| Operation time (min) | –0.139 | –0.171 | 0.159 | –0.204 | –0.085 | –0.057 | - |
| Blood loss (mL) | –0.122 | –0.080 | 0.026 | –0.120 | –0.172 |
–0.097 | - |
| Transfusion | –0.091 | –0.068 | 0.024 | –0.127 | –0.170 |
–0.085 | - |
| No | 3.9 ± 0.4 | 22.3 ± 6.3 | 177 ± 43 | 31 ± 10 | 1644 ± 604 | 40.2 ± 4.0 | |
| Yes (n = 37) | 3.8 ± 0.5 |
19.7 ± 6.5 | 189 ± 68 | 26 ± 10 |
1329 ± 540 |
37.6 ± 7.9 | |
| Postoperative function |
- | ||||||
| Total bilirubin | –0.055 | –0.003 | –0.063 | 0.083 | –0.028 | –0.026 | |
| Alanine aminotransferase | 0.013 | 0.043 | 0.077 | –0.125 | 0.041 | 0.032 | |
| Prothrombin activity | 0.133 | 0.277 |
0.178 |
–0.024 | –0.015 | –0.014 | |
| Platelet | 0.056 | 0.119 | 0.087 | –0.130 | –0.069 | 0.057 | |
| C-reactive protein | 0.020 | –0.007 | 0.083 | –0.061 | 0.090 | 0.032 | |
| Postoperative coarse | |||||||
| Total complication | |||||||
| No | 4.0 ± 0.4 | 22.9 ± 6.3 | 177 ± 40 | 31 ± 9 | 1,612 ± 545 | 40.1 ± 5.4 | 59/72 (55) |
| Yes (n = 45) | 3.8 ± 0.4 |
19.1 ± 6.2 |
187 ± 68 | 28 ± 12 | 1,480 ± 740 | 38.5 ± 4.2 |
28/17 (38) |
| HT-related complication | |||||||
| No | 4.0 ± 0.4 | 22.7 ± 6.3 | 177 ± 39 | 30 ± 10 | 1,597 ± 606 | 40.1 ± 5.3 | 66/82 (75) |
| Yes (n = 28) | 3.7 ± 0.4 |
17.4 ± 4.8 |
189 ± 84 | 27 ± 10 | 1,482 ± 581 | 37.7 ± 4.0 |
21/7 (46) |
| Liver failure | |||||||
| No | 3.9 ± 0.4 | 21.9 ± 6.4 | 180 ± 49 | 30 ± 10 | 1,590 ± 600 | 39.4 ± 5.3 | 84/88 |
| Yes (n = 4) | 3.7 ± 0.3 | 18.5 ± 6.8 | 148 ± 37 | 24 ± 6 | 1,063 ± 490 | 38.9 ± 6.0 | 3/1 |
| Intra-abdominal infection | |||||||
| No | 3.9 ± 0.4 | 22.0 ± 6.5 | 178 ± 46 | 30 ± 10 | 1,589 ± 596 | 39.8 ± 5.2 | 79/84 |
| Yes (n = 13) | 3.8 ± 0.4 | 19.4±5.5 | 197 ± 75 | 30 ± 12 | 1,452 ± 686 | 38.7 ± 4.3 | 8/5 |
| Ascites | |||||||
| No | 3.9 ± 0.4 | 21.8 ± 6.6 | 180 ± 50 | 30 ± 10 | 1,567 ± 606 | 39.7 ± 5.2 | 78/85 |
| Yes (n = 13) | 3.8 ± 0.4 | 20.8 ± 1.4 | 164 ± 33 | 29 ± 13 | 1,718 ± 548 | 38.9 ± 3.8 | 9/4 |
| Bile leak | |||||||
| No | 3.9 ± 0.4 | 22.4 ± 6.2 | 175 ± 39 | 30 ± 10 | 1,598 ± 597 | 39.9 ± 5.2 | 76/84 |
| Yes (n = 16) | 3.6 ± 0.5 |
16.7 ± 6.0 |
215 ± 99 | 24 ± 11 | 1,386 ± 636 | 37.5 ± 4.4 |
11/5 |
| Hospital stay (day) | –0.194 |
–0.267 |
–0.098 | –0.131 | –0.123 | –0.155 |
Values are presented as the mean ± standard deviation. Correlation was indicated as r by Pearson co-efficiency test. Categorical data were examined by chi-squared test. Major hepatectomy included hemihepatectomy or more extended hepatectomy, minor included others.
PNI, Onodera et al. [4]’s Prognostic Nutritional Index; TC, total cholesterol; LN%, lymphocyte rate; LNC, lymphocyte counts; HCC, hepatocellular carcinoma; ICC, intrahepatic cholangiocarcinoma; ECC, extrahepatic cholangiocarcinoma; GBC, gall bladder carcinoma; ICGR15, indocyanine green retention rate at 15 minutes; LHL15, liver uptake ratio of 99m-technetium galactosyl serum albumin scintigraphy between 3 and 15 minutes; HT, hepatectomy; -, not available.
Statistically significant (*
a)Parenthesis showed the prevalence of PNI over 40. b)Maximum or minimum value within 7 days after hepatectomy.