Annals of Hepato-Biliary-Pancreatic Surgery

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Table. 2.

Table. 2.

Univariate analysis of disease-free survival

Variable HR 95% CI p-value
Age (≥ 70/< 70 yr) 0.82 0.34–1.95 0.661
Sex (male/female) 1.00 0.19–1.45 0.601
HBV (+/-) 0.62 0.29–1.28 0.198
HCV (+/-) 1.55 0.41–5.77 0.513
Alcohol (+/-) 3.45 1.05–11.34 0.041
Child-Pugh (B/A) 1.44 0.43–4.82 0.546
Diabetes (+/-) 1.82 0.84–3.93 0.125
Hypertension (+/-) 1.70 0.82–3.49 0.147
Albumin 0.72 0.34–1.51 0.392
Lymphocyte 1.00 0.99–1.00 0.350
Platelet (/mm3) (≤ 1.0 × 105/> 1.0 × 105) 1.16 0.39–3.41 0.784
PT INR (> 1.2/≤ 1.2) 3.20 0.62–16.50 0.164
CRP (mg/dL) 1.16 0.71–1.89 0.535
ALT (U/L) 1.01 0.99–1.02 0.088
Total bilirubin (mg/dL) 1.46 0.60–3.59 0.400
AFP (≥ 40/< 40) 1.61 0.77–3.34 0.198
PIVKA-II (≥ 200/< 200) 2.57 1.23–5.37 0.012
ICG R15 (> 10%/≤ 10%) 3.86 1.71–8.76 0.001
Estimated blood loss (≥ 800 mL/< 800 mL) 2.27 1.05–4.93 0.037
Intraoperative transfusion (+/-) 1.73 0.79–3.82 0.169
Operation time (≥ 300 min/< 300 min) 1.65 0.78–3.49 0.188
Laparoscopic resection (+/-) 0.58 0.28–1.20 0.144
Non-anatomical resection (+/-) 1.10 0.59–2.08 0.748
Major resectiona) (+/-) 1.67 0.82–3.40 0.153
Size (cm) 1.23 1.08–1.40 0.001
Margin (≤ 10 mm/> 10 mm) 0.93 0.46–1.90 0.857
Multiple tumor (+/-) 2.00 0.69–5.78 0.199
Edmondson grade (1/2–4) 1.38 0.45–4.22 0.573
Microvascular invasion (+/-) 2.76 1.14–6.66 0.023
T-stage 2.07 1.38–3.10 0.001
PNI (≥ 52/< 52) 3.50 1.67–7.33 0.001

HR, hazard ratio; CI, confidence interval; HBV, hepatitis B virus; HCV, hepatitis C virus; PT INR, prothrombin time international normalized ratio; CRP, C-reactive protein; ALT, alanine aminotransferase; AFP, alpha fetoprotein; PIVKA-II, prothrombin induced by vitamin K antagonist-II; ICG R15, indocyanine green retention test; PNI, prognostic nutritional index.

a)Resection > 3 segments.

Ann Hepatobiliary Pancreat Surg 2021;25:456-61 https://doi.org/10.14701/ahbps.2021.25.4.456
© 2021 Ann Hepatobiliary Pancreat Surg