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Acute respiratory distress-syndrome in the general complications of severe acute pancreatitis
Ann Hepatobiliary Pancreat Surg 2019 Nov;23(4):359-64
Published online November 30, 2019;
Copyright © 2019 Korean Association of Hepato-Biliary-Pancreatic Surgery.

Ravshan Aliyevich Ibadov1, Anvar Shamkhatovich Arifjanov1, Sardor Khamdamovich Ibragimov1, and Bakhrom Rustamjanovich Abdullajanov2

1Intensive Care Unit, Republican Specialized Scientific-Practical Medical Center of Surgery Named after Academician V.Vakhidov, Tashkent, 2Department of Surgery, Andijan State Medical Institute, Andijan, Uzbekistan
Received February 7, 2019; Revised July 11, 2019; Accepted July 25, 2019.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Backgrounds/Aims: Improvement of efficiency of treatment of patients with severe acute pancreatitis (SAP), complicated by acute respiratory distress-syndrome (ARDS).
Methods: The retrospective research of 67 SAP patients treated at the ICU of the NSSPCS has been conducted from 2008 to 2017. The basic criterion of patient inclusion was stable respiration impairment leading to hypoxia with PaO2/FiO2<300 mmHg that required mechanical ventilatory support.
Results:Pancreatitis-associated ARDS was diagnosed in 36 cases (53.7%). The most frequent clinical form (15 cases) was ARDS of moderate severity (41.5%). The total mortality due to pancreatitis-associated ARDS made 44.5%. Close relationship between ARDS severity and mortality was evident. All lethal outcomes occurred due to progressing multiple organ dysfunction. No deaths were caused by uncontrollable hypoxemia.
Conclusions: The research has confirmed the leading role of pancreatitis-associated ARDS in development and high mortality rate of multiple organ dysfunction syndrome in SAP. Early recognition of the complication and application of ventilatory support techniques resulted in fast restoration of oxygenation and improvement of treatment efficiency.
Keywords : Severe acute pancreatitis; Acute respiratory distress-syndrome; Intensive therapy; Respiratory support


November 2019, 23 (4)