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Differentiation of gallbladder adenomyomatosis from early-stage gallbladder cancer before surgery
Ann Hepatobiliary Pancreat Surg 2019 Nov;23(4):334-8
Published online November 30, 2019;
Copyright © 2019 Korean Association of Hepato-Biliary-Pancreatic Surgery.

Jisum Moon, Yong Chan Shin, Tae-Gil Heo, Pyong Wha Choi, Jae Il Kim, Sung Won Jung, Heungman Jun, Sung Min Jung, and Eunhae Um

Department of Surgery, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea
Received September 17, 2019; Revised October 1, 2019; Accepted October 2, 2019.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Backgrounds/Aims: This study aimed to compare the perioperative and clinical outcomes in patients undergoing laparoscopic cholecystectomy for gallbladder adenomyomatosis (GBA) or early-stage gallbladder cancer (GBC).
Methods: The perioperative and clinical outcomes of 194 patients diagnosed with GBA and 30 patients diagnosed with GBC who underwent laparoscopic cholecystectomy in our institution from January 2011 to December 2017 were retrospectively compared.
Results: There were no significant differences between the GBA and GBC groups in sex (male:female ratio 1.0:0.8 vs. 1.0:0.7, p=0.734), BMI (23.9±3.4 vs. 24.0±3.8 kg/m2, p=0.916), or preoperative liver function tests. Patients in the GBC group were significantly older (50.5±14.1 vs. 65.9±10.6 years, p<0.001) and had a higher ASA grade (40.3 vs. 63.4% grade II or III, p=0.043) than patients in the GBA group. Although there was no significant difference in preoperative diagnostic methods (p=0.442), the GBC group showed a significantly higher rate of misdiagnosis on preoperative imaging compared with postoperative histopathologic findings (30.9% vs. 53.3%, p=0.011). There were significantly more patients with gallstones in the GBA group than in the GBC group (68.6% vs. 40.0%, p=0.004).
Conclusions: In older patients hospitalized for biliary colic without gallstones but with a thickened gallbladder wall with inflammation on preoperative diagnostic exam, the possibility of early-stage GBC should be considered.
Keywords : Gallbladder adenomyomatosis; Gallbladder cancer; Differential diagnosis


November 2019, 23 (4)