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Surgical indications for focal nodular hyperplasia of the liver:Single-center experience of 48 adult cases
Ann Hepatobiliary Pancreat Surg 2019 Feb;23(1):8-12
Published online February 28, 2019;
Copyright © 2019 Korean Association of Hepato-Biliary-Pancreatic Surgery.

Jin-Min Jung, Shin Hwang, Ki-Hun Kim, Chul-Soo Ahn, Deok-Bog Moon, Tae-Yong Ha, Gi-Won Song, and Dong-Hwan Jung

Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Received December 31, 2018; Revised January 5, 2019; Accepted January 10, 2019.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Backgrounds/Aims: Focal nodular hyperplasia (FNH) is one of the most common benign tumors of the liver. There is still a lack of evidence on surgical indications for FNH. This study intended to analyze the surgical indications for FNH.
Methods: We analyzed 48 cases of FNH diagnosed after hepatic resection.
Results: Common reasons leading to surgical resection were diagnostic uncertainty (n=31), and persistent symptoms (n=8). None of our patients had a past history of contraceptive use. Percutaneous biopsy was performed in 14 patients and FNH was diagnosed in nine patients, and hepatic adenoma, hepatocellular carcinoma, plasmacytoma, angiosarcoma, and atypical hepatocellular proliferation in one patient each. Minor hepatectomy (n=37) was performed more frequently than major hepatectomy (n=11). Open hepatectomy (n=29) was performed more frequently than laparoscopic hepatectomy (n=19), but laparoscopic and minimally-invasive surgery was frequently performed during the late phase of the study period. Postoperative surgical complications occurred in two patients (4.1%).
Conclusions: FNH can be diagnosed by imaging studies, but surgical treatment may be considered in cases of diagnostic uncertainty or persistent symptoms.
Keywords : Hepatectomy; Benign disease; Premalignant lesion


February 2019, 23 (1)