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Long term recurrence in primary liver neuroendocrine tumor: Report of a single case and review of literature
Ann Hepatobiliary Pancreat Surg 2018 May;22(2):159-63
Published online May 31, 2018
Copyright © 2018 Ann Hepatobiliary Pancreat Surg.

Giovanni Pirozzolo1, Camilla Cona1,2, Maurizio Rizzo1, Fazli Shala3, Sadri Berisha3, and Alfonso Recordare1

1General and Emergency Surgery Department, Angelo Hospital, Venice, 2University of Padua, Padova, Italy, 3General Surgery Department, Regional Hospital Peja, Peja, Kosovo
Received October 13, 2017; Revised December 17, 2017; Accepted January 14, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Primary liver neuroendocrine tumors (PLNETs) are rare tumors of the liver. They share some common characteristics with neuroendocrine tumors (NETs) of the extrahepatic bile ducts, such as slow rise, hormonal, and histological features. Nevertheless, they possess some peculiarities and the major feature is the difference in the metastatic poten-tial between PLNETs and NETs. PLNETs have less metastatic potential compared with NETs, which is the main factor based on which differential diagnosis between the two groups is achieved. There exists few reports disease’s long-term outcome, especially about the recurrences management. We report the case of a 52-year-old woman admitted to hospi-tal for jaundice and presence of liver mass. She underwent extended right hepatectomy and subsequently, PLNET was revealed. After 9 years, a new mass was discovered in the remnant liver, far from the resection line, and was surgically removed. Histological examination confirmed a PLNET recurrence. The patient is alive and doing well after a year of surgery. We conducted a review of the literature on recurrent PLNETS. Five papers followed our inclusion criteria and included 10 patients. Clinical presentation was mostly nonspecific in included cases and no carcinoid syn-drome was reported. Median overall survival and median disease-free survival periods were 22 and 5 months, respectively. The primary disease was treated with surgical resection in all the included cases and recurrent diseases were mostly treated with non-surgical techniques (mainly transarterial chemoembolization). In conclusion, more studies should be conducted in order to have significant data about this uncommon neoplasm. Finally, considering the lack of data on long-term outcome, a long and accurate follow -up should be considered. (Ann Hepatobiliary Pancreat Surg 2018;22:159-163)
Keywords : Carcinoid tumor; Neuroendocrine tumor; Liver neoplasms; Neoplasm recurrence, local


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