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Xanthogranulomatous pancreatitis mimicking potentially malignant pancreatic neoplasm: report of a case
Ann Hepatobiliary Pancreat Surg 2017 Nov;21(4):243-6
Published online November 30, 2017
Copyright © 2017 Ann Hepatobiliary Pancreat Surg.

Hyung Jun Kwon

Department of Surgery, Kyungpook National University Chilgok Hospital, Kyungpook National University School of Medicine, Daegu, Korea
Received July 21, 2017; Accepted August 13, 2017.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Xanthogranulomatous pancreatitis (XGP) is a rare benign disease that may mimic or accompany other pancreatic diseases. Here we report a case of XGP initially suspected as malignant cystic neoplasm of the pancreas. A 64-year-old man had been incidentally found to have hypodense lesion at the body of pancreas during a lung cancer workup. All laboratory tests were within normal limits except that carcinoembryonic antigen was elevated to 31.3 ng/ml. Imaging study showed 1.8 cm sized, well demarcated, and low-attenuated mass on computed tomography (CT) with heterogeneously high intensity on T2-weighted images of magnetic resonance imaging (MRI). Under the impression of pancreas cystic neoplasm as a rare case of male solid-pseudopapillary tumor or pancreatic metastasis of lung cancer, laparoscopic distal pancreatectomy was performed. Microscopically, the mass had many foamy histiocytes with cholesterol clefts, consistent with xanthogranulomatous inflammation. Therefore, it is important to consider XGP in the differential diagnosis of pancreatic diseases. (Ann Hepatobiliary Pancreat Surg 2017;21:243-246)
Keywords : Xanthogranulomatous; Inflammation; Pancreatitis; Neoplasms


November 2018, 22 (4)