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Primary gigantic leiomyosarcoma of the liver treated with portal vein embolization and liver resection
Ann Hepatobiliary Pancreat Surg 2017 Nov;21(4):228-31
Published online November 30, 2017
Copyright © 2017 Ann Hepatobiliary Pancreat Surg.

Dimitrios Giakoustidis1,2, Alexander Giakoustidis3, Thomas Goulopoulos1, Ntina Arabatzi4, Aristidis Kainantidis1, and Thomas Zaraboukas5

1Department of Surgery, European Interbalkan Medical Centre and 2Division of Transplant Surgery, Department of Surgery, Medical School, Aristotle University of Thessaloniki, Greece, 3Department of HPB Surgery, Royal London Hospital, London, UK, 4Department of Anesthesiology, European Interbalkan Medical Centre, 5Histodierevnitiki Laboratory of Pathology, European Interbalkan Medical Centre, Thessaloniki, Greece
Received July 7, 2017; Revised August 13, 2017; Accepted August 13, 2017.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Primary hepatic leiomyosarcoma (PHL) is an extremely rare tumor. The tumor has no specific presentations and often diagnosis is delayed until it reaches a significant size. We report the case of a 69-year-old female presented with a huge PHL. Due to size of the tumor and to be operable, the patient subjected to right portal vein embolization (PVE) and selective embolization of segment V. Four weeks after the PVE, liver resection was conducted (Segments V+ VI bisegmentectomy plus resection of IVA). The patient had an uncomplicated post-operative course, and discharged at the 8th post-operative day. Diagnosis of PHL was confirmed by histopathological and immunohistochemical examinations. The patient refused to receive adjuvant chemotherapy, and revealed evidence of recurrence six months after the operation, and finally died 12 months after the operation and 16 months after initial diagnosis. PHL is an extremely rare tumor and often in first presentation has significant size. Radical surgery with adjuvant chemotherapy is key feature for prolonged survival. (Ann Hepatobiliary Pancreat Surg 2017;21:228-231)
Keywords : Primary hepatic leiomyosarcoma; Portal vein embolization; Liver resection


November 2018, 22 (4)