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Gallstone, cholecystectomy and risk of gastric cancer
Ann Hepatobiliary Pancreat Surg 2017 Aug;21(3):131-7
Published online August 31, 2017
Copyright © 2017 Ann Hepatobiliary Pancreat Surg.

Sung Hwa Kang1, Young Hoon Kim1, Young Hoon Roh1, Kwan Woo Kim1, Chan Joong Choi1, Min Chan Kim1, Su Jin Kim1, Hee Jin Kwon2, Jin Han Cho2, Jin Seok Jang3, and Jong Hun Lee3

1Department of Surgery, 2Department of Radiology, 3Department of Internal Medicine, Dong-A University Hospital, Busan, Korea
Received April 21, 2017; Revised July 7, 2017; Accepted July 8, 2017.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Backgrounds/Aims: The aim of this retrospective study is to compare stomach cancer incidence, characteristics be-tween gallstones, cholecystectomy and control groups. It also aims to investigate key variables’ potential effects on overall survival. Methods: A total of 99 patients, diagnosed with stomach cancers between April 1994 and December 2015, were identified. We excluded stomach cancer patients, accrued during the first year of follow-up in both the gallstones and cholecystectomy groups, assuming that they missed cancers. The main analyses addressing the ob-jective were a chi-square analysis and a survival analysis. Results: The incidence of stomach cancers was increased in both the gallstone and cholecystectomy groups, compared with the control group (p=0.003). Multivariate regression analysis showed that the overall survival in gallstones, cholecystectomy group patients as compared with those in the control group decreased (HR=6.66, 95 CI: 1.94-22.80, p=0.003). Also, T-stage was found to statistically affect the rate of overall survival (HR=9.85, 95% CI: 3.09-31.39, p=.000). The stomach cancer showed the worse survival at the posterior, greater curvature location than anterior, lesser curvature of the stomach. (HR=0.30, 95% CI: 0.11-0.80, p=0.017). Conclusions: We provided an awareness of the possible increased risks of stomach cancer in gallstone and cholecystectomy group patients, which might be induced by duodenogastric bile reflux. Also, the survival rate was poor (p<0.000). Therefore, close follow-up strategies for early detection are recommended for such patients. (Ann Hepatobiliary Pancreat Surg 2017;21:131-137)
Keywords : Stomach cancer; Gallstones; Cholecystectomy