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Clinicopathological features and post-resection outcomes of biliary cystadenoma and cystadenocarcinoma of the liver
Ann Hepatobiliary Pancreat Surg 2017 Aug;21(3):107-13
Published online August 31, 2017
Copyright © 2017 Ann Hepatobiliary Pancreat Surg.

Eun-Kyoung Jwa, and Shin Hwang

Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Received July 15, 2017; Revised August 10, 2017; Accepted August 16, 2017.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Backgrounds/Aims: Biliary cystadenoma (BCA) and biliary cystadenocarcinoma (BCAC) account for 5%-10% of liver cystic diseases. In this study, we analysed the clinical presentation and surgical management of patients with BCA and BCAC. Methods: We retrospectively analysed the medical records of 23 BCA and 7 BCAC cases diagnosed be-tween January 2007 and December 2013. Results: There was a statistically significant difference in age (p=0.044) and sex (p=0.048) between BCA and BCAC groups. In the BCA group, 17 patients showed no symptoms (74%), 5 had abdominal pain (22%) and 1 showed abdominal distension (4%). In the BCAC group, two patients were without any symptoms (29%), three had abdominal pain (43%), one showed abdominal distension (14%) and one had fever and chills (14%). The cystic lesion size was widely variable; thus, there was no statistical difference (p=0.84). Complete resection was performed in all patients with BCA and BCAC. No tumour recurrence developed in patients with BCA. In patients with BCAC, 1-, 3- and 5-year disease-free survival rates were 100%, 85.7% and 57.1%, respectively, and 1-, 3- and 5-year overall patient survival rates were 100%, 100% and 75.0%, respectively. Conclusions: It is difficult to distinguish between BCA and BCAC via clinical manifestations and diagnostic imaging findings. Surgical resection is the treatment of choice for BCA and BCAC, and patient prognosis after complete resection was very favourable. (Ann Hepatobiliary Pancreat Surg 2017;21:107-113)
Keywords : Cholangiocarcinoma; Resection; Bile duct; Malignant change; Premalignant lesion