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Prognostic value of COL6A3 in pancreatic adenocarcinoma
Ann Hepatobiliary Pancreat Surg 2020 Feb;24(1):52-6
Published online February 29, 2020;
Copyright © 2020 Korean Association of Hepato-Biliary-Pancreatic Surgery.

Christos Svoronos1, Georgios Tsoulfas2, Maria Souvatzi3, and Efthimios Chatzitheoklitos4

1Department of Surgery, AMEOS Klinikum, Halberstadt, Germany, 2First Department of Surgery, Aristotle University of Thessaloniki, Thessaloniki, Greece, 3St Mary’s Hospital Imperial College Healthcare NSH Trust, London, UK, 4Unit of Pancreatic Surgery, Interbalkan Center, Thessaloniki, Greece
Received October 2, 2019; Revised November 29, 2019; Accepted December 2, 2019.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Backgrounds/Aims: Pancreatic cancer is one of the most fatal human malignancies with poor prognosis, despite advances in therapy. Here, we evaluated the potential role of collagen type VI α3 chain (COL6A3) as a non-invasive biomarker for pancreatic adenocarcinoma.
Methods: In this study, we investigated immunohistochemically the expression of COL6A3 in 30 patients with resectable pancreatic adenocarcinoma by immunohistochemistry in a tissue sample of the cancer and a tissue sample of normal pancreas for each patient. Also, we looked for associations between COL6A3 and other prognostic factors of pancreatic cancer.
Results: All of the pancreatic cancer tissue samples revealed in different ranges of intensity from weak (+1) in 16.67%, moderate (+2) in 50%, to strongly positive (+3) in 33.33% staining for COL6A3. We found no moderate or strongly positive staining in normal pancreatic tissue. There was only weak positive staining in 23 samples (76.67%) and 7 (23.30%) were negative. Also, there was significant correlation between COL6A3 moderate and strongly expression and negative prognostic factors for pancreatic cancer.
Conclusions: The greatest density of COL6A3 was observed in pancreatic cancer tissues and was correlated with negative prognostic factors for pancreatic cancer. Therefore, we suggest that COL6A3 could be used as prognostic factor in pancreatic cancer, but more studies need to prove its value.
Keywords : Pancreatic adenocarcinoma; COL6A3; Prognosis