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Gallbladder agenesis: A case report and brief review 
Ann Hepatobiliary Pancreat Surg 2018 Aug;22(3):292-5
Published online August 31, 2018
Copyright © 2018 Ann Hepatobiliary Pancreat Surg.

Giuseppe Bianco1, Francesco Frongillo1, Salvatore Agnes1, Erida Nure1, Nicola Silvestrini2

1Department of Surgery - Transplantation Service Catholic University of the Sacred Heart, Rome,  2Department of Surgery Ospedale Generale Provinciale, Macerata, Italy
Received November 19, 2017; Revised February 27, 2018; Accepted April 23, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Agenesis of the gallbladder and cystic duct represents one of the rarest anomalies of the biliary system, with a reported incidence of 0.007% to 0.027%. Almost half of the patients develop common duct stones and 23% of them manifest signs and symptoms that mimic biliary colic. We present the case of a woman presenting with symptoms of biliary colic. Based on the clinical findings and after abdominal ultrasonography, which showed hyperechoic material in the gallbladder fossa, a laparoscopic cholecystectomy was planned. Laparoscopy failed to reveal either gallbladder or cystic duct. The procedure was continued to further search for ectopic sites of gallbladder. A condition of gallbladder agenesis was hypothesized and the procedure was aborted without dissection of hepatic pedicle or conversion to laparotomy. Agenesis of gallbladder and cystic duct was confirmed via pos-operative magnetic resonance cholangiopancreatography. We report our experience with regard to the challenges associated with the diagnosis and management, and a brief review of the literature of this rare pathology.
Keywords : Gallbladder agenesis; Laparoscopic cholecystectomy; Congenital abnormalities of the biliary tract