Annals of Hepato-Biliary-Pancreatic Surgery

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Table. 3.

Table. 3.

Univariate survival analysis (Cox Regression proportional hazard model)

1 year survival (n=97) 3 year survival (n=86) 5 year survival (n=60)



Overall survival Disease free survival Overall survival Disease free survival Overall survival Disease free survival






Hazard ratio (95% C.I.) p-value Hazard ratio (95% C.I.) p-value Hazard ratio (95% C.I.) p-value Hazard ratio (95% C.I.) p-value Hazard ratio (95% C.I.) p-value Hazard ratio (95% C.I.) p-value
Male sex 0.86 (0.33-2.18) 0.75 0.87 (0.37-2.01) 0.74 1.34 (0.61-2.93) 0.46 1.28 (0.60-2.71) 0.52 0.90 (0.41-1.99) 0.8 0.90 (0.41-1.96) 0.79
Weight loss 0.92 (0.34-2.49) 0.87 0.76 (0.31-1.84) 0.54 1.12 (0.48-2.58) 0.78 0.83 (0.38-1.79) 0.63 0.94 (0.41-2.18) 0.89 0.92 (0.40-2.13) 0.86
Diabetes mellitus 1.35 (0.47-3.84) 0.57 1.27 (0.49-3.23) 0.61 3.11 (1.43-6.76) 0.004* 2.61 (1.23-5.53) 0.01* 3.32 (1.46-7.53) 0.004* 2.87 (1.29-6.41) 0.009*
DM subset
New onset DM 1.82 (0.51-6.52) 0.35 1.44 (0.41-5.01) 0.56 3.86 (1.53-9.73) 0.004* 3.27 (1.33-8.05) 0.01* 3.39 (1.21-9.51) 0.02* 2.97 (1.07-8.21) 0.036*
Long standing DM 1.62 (0.45-5.79) 0.46 1.64 (0.54-4.99) 0.38 3.31 (1.25-8.73) 0.016* 2.69 (1.04-6.96) 0.041* 3.25 (1.16-9.08) 0.024* 2.79 (1.01-7.67) 0.047*
Pylorus resecting surgery 18.17 (2.41-136.7) 0.004* 4.93 (1.66-14.61) 0.004* 3.20 (1.4-7.33) 0.006* 3.56 (1.57-8.05) 0.002* 2.31 (1.05-5.09) 0.03* 2.18 (1.01-4.73) 0.04*
Pancreatic tumor vs non pancreatic periampullary tumor 5.81 (2.25-15.05) 0.0002* 4.618 (1.99-10.73) 0.0003* 3.06 (1.42-6.61) 0.0044* 3.28 (1.56-6.89) 0.0017* 1.71 (0.68-4.29) 0.25 1.69 (0.68-4.23) 0.25
T Stage
T2 3.49 (0.42-28.41) 0.24 4.15 (0.51-33.22) 0.18 3.21 (0.69-14.91) 0.13 1.57 (0.48-5.11) 0.45 1.66 (0.78-5.90) 0.43 1.85 (0.54-6.34) 0.32
T3 2.91 (0.42-27.47) 0.24 4.80 (0.62-37.22) 0.13 4.08 (0.93-17.81) 0.06 2.07 (0.69-6.19) 0.19 2.35 (0.76-7.23) 0.13 2.30 (0.75-7.07) 0.14
T4 1.11×10−7 (0.00-inf) 0.99 1.39×10−7 (0.0-inf) 0.99 1.1×10−7 (0-Inf) 0.99 6.15×10−8 (0-Inf) 0.99 1.14 (0.12-10.27) 0.9 1.11 (0.12-9.99) 0.92
Positive lymph node 2.29 (0.85-6.17) 0.09 2.19 (0.91-5.29) 0.08 2.56 (1.17-5.59) 0.01* 2.04 (0.96-4.32) 0.06 3.52 (1.53-8.09) 0.003* 2.96 (1.31-6.69) 0.008*
Differentiation
Moderate 2.23 (0.48-10.19) 0.3 1.75 (0.49-6.21) 0.38 1.73 (0.63-4.72) 0.28 1.21 (0.49-2.95) 0.67 1.77 (0.70-4.51) 0.22 1.48 (0.61-3.59) 0.37
Poor 4.08 (0.36-45.08) 0.25 2.94 (0.30-28.38) 0.34 1.77 (0.21-15.20) 0.6 1.32 (0.16-10.81) 0.79 5.53×10−8 (0.0-inf) 0.99 4.94×10−8 (0.00-inf) 0.99
Positive resection margin 4.94 (1.58-15.39) 0.005* 4.59 (1.53-13.82) 0.006* 2.87 (0.99-8.33) 0.051* 4.46 (1.69-11.76) 0.002* 3.00 (1.02-8.82) 0.04* 3.23 (1.13-9.75) 0.02*
Adjuvant therapy 0.65 (0.25-1.64) 0.36 0.69 (0.30-1.61) 0.39 0.78 (0.36-1.66) 0.52 0.91 (0.43-1.88) 0.79 2.04 (0.84-4.94) 0.11 1.77 (0.76-4.12) 0.18

CI, confidence interval; DM, diabetes mellitus; inf, infinity

*meaning data with significant p-values

Please see table 5 for number of patients in each parameters in 1, 3 and 5 years survival analysis

Ann Hepatobiliary Pancreat Surg 2021;25:230-41 https://doi.org/10.14701/ahbps.2021.25.2.230
© 2021 Ann Hepatobiliary Pancreat Surg